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  • NICE - Endorsed Technology Appraisals 2018/2019

    Topics:
    • Safety and quality, 
    • NICE technology appraisals

    It is important to note that the advice contained within the guidance does not override or replace the individual responsibility of health professionals to make appropriate decisions in the circumstances of their individual patients, in consultation with the patient and/or guardian or carer. This would, for example, include situations where individual patients have other conditions or complications that need to be taken into account in determining whether the NICE guidance is fully appropriate in their case.

    Technology Appraisals Endorsement Process

    The Department has reviewed its process for the endorsement, implementation, monitoring and assurance of NICE Technology Appraisals in Northern Ireland. The new arrangements are detailed in following circulars, which is effective from 18th December 2013;

    NICE Technology Appraisals – Process for Endorsement, Implementation, Monitoring and Assurance in Northern Ireland – HSC (SQSD) 02/13.

    For information, details of the previous arrangement can be found on the following circular;

    NICE Technology Appraisals and Clinical Guidelines – New Process for Endorsement, Implementation, Monitoring and Assurance in Northern Ireland – HSC (SQSD) 04/11

    2018/2019

    The following technology appraisals have been endorsed during 2017/18. Information on technology appraisals endorsed in previous years can be found on the homepage.

    Fully Endorsed

    March 2019

    NICE TA 540 - Pembrolizumab for treating relapsed or refractory classical Hodgkin lymphoma - Note this guidance has been partially updated and replaced by TA967 - Pembrolizumab for treating relapsed or refractory classical Hodgkin lymphoma in people 3 years and over, endorsed by the DoH in May 2024.

    NICE TA 553 - Pembrolizumab for adjuvant treatment of resected melanoma with high risk of recurrence - Note this guidance has been updated and replaced by TA766 - Pembrolizumab for adjuvant treatment of completely resected stage 3 melanoma, which was endorsed by the DoH in February

    NICE TA 557 - Pembrolizumab with pemetrexed and platinum chemotherapy for untreated, metastatic, non-squamous non-small-cell lung cancer - Note this guidance has been updated and replaced by TA683 - Pembrolizumab with pemetrexed and platinum chemotherapy for untreated, metastatic, non-squamous non-small-cell lung cancer, which was endorsed by the DoH in April 2021.

    NICE TA 554 - Tisagenlecleucel for treating relapsed or refractory B-cell acute lymphoblastic leukaemia in people aged ups to 25 years

    Note this guidance has been updated and replaced by TA975 - Tisagenlecleucel for treating relapsed or refractory B-cell acute lymphoblastic leukaemia in people 25 years and under, endorsed by the DoH in June 2024.

    NICE TA 558 - Nivolumab for adjuvant treatment of completely resected melanoma with lymph node involvement or metastatic disease - Note this guidance has been updated and replaced by TA684 - Nivolumab for adjuvant treatment of completely resected melanoma with lymph node involvement or metastatic disease, which was endorsed by the DoH in April 2021.

    NICE TA 561 - Venetoclax with rituximab for previously treated chronic lymphocytic leukaemia

    NICE TA 562 - Encorafenib with binimetinib for unresectable or metastatic BRAF V600 mutation-positive melanoma

    NICE TA 563 - Abemaciclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer

    February 2019

    NICE TA 487 - Venetoclax for treating chronic lymphocytic leukaemia

    ‘Note this guidance has been updated and replaced by TA796 - Venetoclax for treating chronic lymphocytic leukaemia, which was endorsed by the DoH in July 2022’

    NICE TA 490 - Nivolumab for treating squamous cell carcinoma of the head and neck after platinum-based chemotherapy ‘Note this guidance has been updated and replaced by TA736 - Nivolumab for treating recurrent or metastatic squamous cell carcinoma of the head and neck after platinum-based chemotherapy, which was endorsed by the DoH in November 2021.’

    NICE TA 491 - Ibrutinib for treating Waldenstrom’s macroglobulinaemia

    ‘Note this guidance has been updated and replaced by TA795 - Ibrutinib for treating Waldenstrom’s macroglobulinaemia, which was endorsed by the DoH in July 2022’

    NICE TA 492 - Atezolizumab for untreated PD-L1-positive locally advanced or metastatic urothelial cancer when cisplatin is unsuitable - Note this guidance has been updated and replaced by TA739 - Atezolizumab for untreated PD-L1-positive advanced urothelial cancer when cisplatin is unsuitable, which was endorsed by the DoH in November 2021.

    NICE TA 505 - Ixazomib with lenalidomide and dexamethasone for treating relapsed or refractory multiple myeloma

    ‘Note this guidance has been updated and replaced by TA870 - Ixazomib with lenalidomide and dexamethasone for treating relapsed or refractory multiple myeloma, endorsed by the DoH in March 2023.’

    NICE TA 510 - Daratumumab monotherapy for treating relapsed and refractory multiple myeloma

    ‘Note this guidance has been updated and replaced by TA783 - Daratumumab monotherapy for treating relapsed and refractory multiple myeloma, which was endorsed by the DoH in May 2022’.

    NICE TA 517 - Avelumab for treating metastatic Merkel cell carcinoma

    • This update and replaces NICE TA 517 - Avelumab for treating meteatatic Merkel cell carcinoma, which was endorsed by the DoH in May 2018.
    • Note this guidance has been partially updated and replaced by TA691 - Avelumab for untreated metastatic Merkel cell carcinoma, which was endorsed by the DoH in May 2021.

    NICE TA 519 - Pembrolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy - Note this guidance has been updated and replaced by TA692 - Pembrolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy, which was endorsed by the DoH in May 2021

    NICE TA 522 - Pembrolizumab for untreated PD-L1-positive locally advanced or metastatic urothelial cancer when cisplatin is unsuitable - Note this guidance has been updated and replaced by NICE Technology Appraisal TA674 - Pembrolizumab for untreated PD-L1-positive, locally advanced or metastatic urothelial cancer when cisplatin is unsuitable (terminated appraisal)

    NICE TA 529 - Crizotinib for treating ROS1-positive advanced non-small-cell lung cancer Note this guidance has been updated and replaced by TA1021 - Crizotinib for treating ROS1-positive advanced non-small-cell lung cancer, endorsed by the DoH in December 2024

    January 2019

    NICE TA 550 - Vandetanib for treating medullary thyroid cancer

    NICE TA 551 - Lenvatinib for untreated advanced hepatocellular carcinoma

    NICE TA 552 - Liposomal cytarabine–daunorubicin for untreated acute myeloid leukaemia

    NICE TA 555 - Regorafenib for previously treated advanced hepatocellular carcinoma (rapid review of TA514) - Note this guidance updates and replaces NICE Technology Appraisal TA514, which was endorsed by the DoH in April 2018.

    NICE TA 556 - Darvadstrocel for treating complex perianal fistulas in Crohn’s disease

    NICE TA 472 - Obinutuzumab with bendamustine for treating follicular lymphoma refractory to rituximab Note this guidance has been updated and replaced by TA629 - Obinutuzumab with bendamustine for treating follicular lymphoma after rituximab, which was endorsed by the DoH in July 2020

    NICE TA 483 - Nivolumab for previously treated squamous non-small-cell lung cancer Note this guidance has been updated and replaced by TA655 - Nivolumab for advanced squamous non-small-cell lung cancer after chemotherapy, which was endorsed by the DoH in November 2020.

    NICE TA 528 - Niraparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube and peritoneal cancer

    ‘Note this guidance has been updated and replaced by TA784 - Niraparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube and peritoneal cancer, which was endorsed by the DoH in May 2022’.

    NICE TA 484 - Nivolumab for previously treated non-squamous non-small-cell lung cancer - Note this guidance has been updated and replaced by TA713 - Nivolumab for advanced non-squamous non-small-cell lung cancer after chemotherapy, which was endorsed by the DoH in August 2021

    December 2018

    NICE TA 547 - Tofacitinib for moderately to severely active ulcerative colitis

    November 2018

    NICE TA 544 - Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanoma

    NICE TA 545 - Gemtuzumab ozogamicin for untreated acute myeloid leukaemia

    NICE TA 546 - Padeliporfin for untreated localised prostate cancer

    October 2018

    NICE TA 541 - Inotuzumab ozogamicin for treating relapsed or refractory B-cell acute lymphoblastic leukaemia

    NICE TA 542 - Cabozantinib for untreated advanced renal cell carcinoma

    NICE TA 543 - Tofacitinib for treating active psoriatic arthritis after inadequate response to DMARDs

    September 2018

    NICE TA 538 - Dinutuximab beta for treating neuroblastoma

    NICE TA 537 - Ixekizumab for treating active psoriatic arthritis after inadequate response to DMARDs

    NICE TA 536 - Alectinib for untreated ALK-positive advanced non-small-cell lung cancer

    NICE TA 535 - Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine

    NICE TA 539 - Lutetium (177Lu) oxodotreotide for treating unresectable or metastatic neuroendocrine tumours

    August 2018

    NICE TA 532 - Cenegermin for treating neurotrophic keratitis

    NICE TA 527 - Beta interferons and glatiramer acetate for treating multiple sclerosis (review of TA32)

    NICE TA 530 - Nivolumab for treating locally advanced unresectable or metastatic urothelial cancer after platinum-containing chemotherapy

    NICE TA 531 - Pembrolizumab for untreated PD-L1-positive metastatic non-small-cell lung cancer (review of TA447)

    NICE TA 533 - Ocrelizumab for treating relapsing–remitting multiple sclerosis

    NICE TA 534 - Dupilumab for treating moderate to severe atopic dermatitis

    June 2018

    NICE TA 520 - Atezolizumab for treating locally advanced or metastatic non-small-cell lung cancer after chemotherapy

    NICE TA 521 - Guselkumab for treating moderate to severe plaque psoriasis

    NICE TA 523 - Midostaurin for untreated acute myeloid leukaemia

    NICE TA 524 - Brentuximab vedotin for treating CD30-positive Hodgkin lymphoma (review of TA446)

    • This guidance updates and replaces NICE Technology Appraisal TA446, which was endorsed by the DoH in July 2017.

    NICE TA 525 - Atezolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy

    May 2018

    ​NICE TA 518 - Tocilizumab for treating giant cell arteritis

    April 2018

    NICE TA 511 - Brodalumab for treating moderate to severe plaque psoriasis

    NICE TA 512 - Tivozanib for treating advanced renal cell carcinoma

    NICE TA 513 - Obinutuzumab for untreated advanced follicular lymphoma

    NICE TA 514 - Regorafenib for previously treated advanced hepatocellular carcinoma

    • This guidance has been updated and replaced by TA555 - Regorafenib for previously treated advanced hepatocellular carcinoma, which was endorsed by the DoH in January 2019.

    NICE TA 515 - Eribulin for treating locally advanced or metastatic breast cancer after 1 chemotherapy regimen (review of TA250)

    • This guidance updates and replaces NICE Technology Appraisal TA250, which was endorsed by the DoH in May 2012.

    NICE TA 516 - Cabozantinib for treating medullary thyroid cancer

    Related content

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    • NICE - Endorsed Technology Appraisals 2007/2008
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    • NICE - Endorsed Technology Appraisals 2009/2010
    • NICE - Endorsed Technology Appraisals 2010/2011
    • NICE - Endorsed Technology Appraisals 2011/2012
    • NICE - Endorsed Technology Appraisals 2012/2013
    • NICE - Endorsed Technology Appraisals 2013/2014
    • NICE - Endorsed Technology Appraisals 2014/2015
    • NICE - Endorsed Technology Appraisals 2015/2016
    • NICE - Endorsed Technology Appraisals 2016/2017
    • NICE - Endorsed Technology Appraisals 2017/2018
    • NICE - Endorsed Technology Appraisals 2019/2020
    • NICE - Endorsed Technology Appraisals 2020/2021
    • NICE - Endorsed Technology Appraisals 2021/2022
    • NICE - Endorsed Technology Appraisals 2022/2023
    • NICE - Endorsed Technology Appraisals 2023/2024
    • NICE - Endorsed Technology Appraisals 2024/2025
    • NICE Technology Appraisals
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